D.E. Wells, R.M. Showman, W.H. Klein and R.A. Raff. (1981) Delayed recruitment of maternal H3 mRNA in the sea urchin embryo. Nature 292:477-478.
A.M. Bruskin, A.L. Tyner, D.E. Wells, R.M. Showman and W.H. Klein. (1981) Accumulation in embryogenesis of five mRNAs enriched in the ectoderm of the sea urchin pluteus. Developmental Biology 87:308-314.
D. E Wells and C. Moser. (1982) Influence of vasopression and oxytocin on neoteny in the adult Mexican Axolotl, Journal of Experimental Zoology, 221:173-179.
D.E. Wells, A.M. Bruskin, D.A. O'Brochta and R.A. Raff. (1982) Prevalent RNA sequences of mitochondrial origin in the sea urchin embryo. Developmental Biology 92:557.
R.M. Showman, D.E. Wells J.A. Anstrom, D.A. Hursh and R.A. Raff. (1982) Message specific sequestration of maternal histone mRNA in the sea urchin egg. Proceedings of the National Academy of Science USA 79:5944.
R.M. Showman, D.E. Wells, J.A. Anstrom, D.A. Hursh, D.S. Leaf, and R.A. Raff. (1984) "Subcellular localization of maternal histone mRNAs and the control of histone synthesis in the sea urchin embryo", in Molecular Aspects of Early Development, Malacinski & Klein eds., Plenum, N.Y., pp. 109-130.
L.M. Angerer, D.V. DeLeon, R.C. Angerer, R.M. Showman, D.E. Wells and R.A. Raff. (1984) Delayed accumulation of maternal histone mRNA during sea urchin oogenesis. Developmental Biology 101:477.
R.A. Raff, J.A. Anstrom, C.H. Huffman, D.S. Leaf, J.H. Loo, R.M. Showman, D.E. Wells. (1984) Evolutionary change in developmental expression of a class of highly conserved genes. Nature 310:312.
D.E. Wells and L.H. Kedes. (1985) Structure of a human histone cDNA: Evidence that basally expressed histone genes have intervening sequences and encode poly-adenylated mRNAs. Proceedings of the National Academy of Science USA 82:2834.
R.M. Showman, D.E. Wells, J.A. Anstrom, D.A. Hursh, D.S. Leaf, and R.A. Raff. (1985) Maternal Messenger RNA: Synthesis and Cytoplasmic Localization of Histone in RNAs in the Sea Urchin Oocyte , in Cellular & Molecular Biology of Invertebrate Development, Belle & Baruch Library in Marine Science, Vol. 15., ed. R. Sawyer & R.M. Showman, U.S.C. Press, Columbia, pp. 153-170.
D. E. Wells. (1986) Alignment analysis of histone genes and proteins. Nucleic Acids Research 14:119-149.
D.E. Wells, W. Bains and L.H. Kedes. (1986) Evolution of histone gene families: codon usage in higher eucaryotes reflects functional rather than phylogenetic relationships. Journal of Molecular Evolution 23:224-242.
D.E. Wells, J.A. Anstrom, R.A. Raff, S.Murray, R.M. Showman. (1986) Maternal stores of alpha-subtype histone mRNA are not required for normal early development of sea urchin embryos. Roux Archieves of Developmental Biology 195:252-259.
D. Reines, D.E. Wells, M. J. Chamberlin and C.M. Kane. (1987) RNA polymeraseII terminates transcription within eucaryoyic gene sequences transcribed in vitro. J. Molecular Biology 196:27-41.
D.E. Wells, D. Hoffman and L.H. Kedes. (1987) Unusual structure, evolutionary conservation of non-coding sequences and numerous processed pseudogene characterize the human h3.3 histone multigene family. Nucleic Acids Research 15:2871-2889.
D.E. Wells and J.Herrmann. (1989) Non-Random Codon Usage in Histone Genes. International Journal of Biochemistry 21:1-6.
D.E Wells and C. McBride. (1989) A comprehensive compilation and alignment of histones and histone genes. Nucleic Acids Research 17:311-346.
M. Chalmers and D.E. Wells. (1990) Extreme sequence conservation characterizes the rabbit H3.3A histone cDNA. Nucleic Acids Research 18:3075.
M. Wagner, Y. Ge, M. Siciliano and D.E. Wells. (1991) A hybrid cell mapping panel for the regional localization of probes to human chromosome 8. Genomics 11:114-125.
D. Porter, D. Brown and D.E.Wells. (1991) The H3-H4 histone gene pair in the marine copepod Tigriopus californicus, contains an intergenic dyad symmetry element. DNA Sequence 1:197-206.
J. E. Parrish, M. J. Wagner, J. T. Hecht, C. I. Scott and D. E. Wells. (1991) Molecular analysis of overlapping chromosomal deletions in patients with Langer-Giedion Syndrome, Genomics 11:54-61.
D.E. Wells and D. Brown. (1991) Histones and histone gene compilation and alignment update. Nucleic Acids Research 19:2173-2188.
H. Ludecke, C. Johnson, M.J. Wagner, D.E. Wells, C. Turleau, N. Tommerup, A. Latos- Bielenska, K-R. Sandig, P. Meinecke, B. Zabel and B. Horstemke. (1991) Molecular definition of the shortest region of overlap in the Langer-Giedion Syndrome. American Journal of Human Genetics 49:1197-1206.
K. Kaneko, M.J. Wagner, D.E. Wells, H. Tanaka, T. Miyatake and S. Tsuji. (1991) A new RFLP locus D8S163 maps to human chromosome 8pter-8p22. Nucleic Acids Research 19:6059.
D.E. Wells and W. Bains. (1991) The genomic structure of an unusual human H3.3 histone pseudogene. DNA Sequence 2:125-127.
Y.Ge, M.J. Wagner, M. Siciliano and D.E. Wells. (1992) Sequence, higher order repeat structure, and long range organization of alpha satellite sequences specific to human chromosome 8. Genomics 13:185-193.
D. Brown, A. Cook, M. Wagner and D.E. Wells. (1992) Closely linked H2B genes in the marine copepod, Tigriopus californicus indicate a recent duplication/gene conversion event. DNA Sequence 2:387-396.
A.W. Cottingham, L.A. Sadler, S.H. Blanton, M.J. Wagner, D.E. Wells, J.R. Heckenlively and S.P. Daiger. (1992) A tight linkage cluster, with two new RFLPs (D8S96 and D8S108), in the interval 8cen-q13. Nucleic Acids Research 20:1426.
J. Tomfohrde, S. Wood, M. Schertzer, M.J. Wagner, D.E. Wells, J. Parrish, L.A. Sadler, S.H. Blanton, S.P. Daiger, Z. Wang. P.J. Wilkie, and J.L. Weber. (1993) Human chromosome 8 linkage map based on short tandem repeat polymorphisms: Effect of genotyping errors. Genomics 14: 144-152.
J. Gu, L.A. Sadler, S.P. Daiger, D.E. Wells and M.J. Wagner. (1993). Dinucleotide repeat polymorphism at the CRH gene. Human Mol. Genet. 2: 85.
A. Cook, W. Raskind, S. Blanton, R. Pauli, R. Gregg, C. Francomano, E. Conrad, G. Schmale, G. Schellenberg, E. Wijman, J. Hecht, D.E. Wells and M. Wagner, (1993) Genetic Heterogeneity in families with Hereditary Multiple Exostoses. American Journal of Human Genetics 53: 71-79.
C.B.J.M. Cleutjens, C.C.E.M. van Eekelen, , H. van Dekken, E.M.E. Smit, A. Hagemeijer, M.J. Wagner, D.E. Wells, J. and Trapman. (1993) The human C/EBPd (CRP3/CELF) gene: Structure and chromosomal localization. Genomics 16: 520-523.
S. Wood, K. Ben Othmane, U. Bergerheim, S. Blanton, R. Bookstein, R. Clarke, S. Daiger, H. Donis-Keller, D. Drayna, S. Kumar, R. Leach, H-J. LŸdecke, J. Oshima, J., L. Sadler, N. Spurr, T. Steinbrueck, J. Trapman, M. Wagner, Z. Wang, Z., D. Wells, C. and Westbrook. (1993) Report of the first international workshop on human chromosome 8 mapping. Cytogenet. Cell Genet. 64: 133-146.
A.I. Ishaq, S.B. Rizvi., D.E. Wells and C.R. Tomlinson. (1993) A characterization of the H3 and H4 histone genes from the ascidian Stylea plicata" Biochem. Biophys. Res. Comm. 194:775-783.
M. Sapru, J.Gu, X. Gu, D. Smith, C-E.Yu, D.E. Wells and M.J. Wagner. (1994) A panel of radiation hybrids for human chromosome 8. Genomics 21: 208-216.
L. Ni, M.J. Wagner, W.J. Kimberling, M.E. Pembrey, K.M. Grundfast, S. Kumar, S. P. Daiger, D.E. Wells, K. Johnson, and R.J.L. Smith. (1994) Refined localization of the branchio-otorenal syndrome gene by linkage and haplotype analysis. Am. J. Med. Genet. 51: 176-184.
J.E. Parrish, Y. Wang, M.J. Wagner and D.E. Wells. (1994) Alignment of the physical and genetic maps of human 8q23-qter using a somatic cell hybrid mapping panel. Somat. Cell Mol. Genet. 20: 143-146.
D. MacGrogan, A. Levy, D. Bostwick, M.J. Wagner, D.E. Wells and R. Bookstein. (1994) Loss of chromosome 8p loci in prostate cancer: mapping by quantitative allelic imbalance. Genes, Chromosomes and Cancer 10:151-159.
L. Sullivan, J. Parrish, M.J. Wagner, D.E.Wells, S. H. Blanton and S.P. Daiger. (1994) Tetranucleotide repeat ploymorphism (D8S582) for human EST00680 (D8S340E) Human Molec. Genet. 3: 386.
J. Oshima, C.E. Yu, M. Boehnke, J.L. Weber. S. Edelhoff, M.J. Wagner, D.E. Wells, S. Wood, C.M. Disteche, G.M. Martin and G.D. Schellenberg. (1994) Integrated mapping analysis of the Werner's syndrome region of chromosome 8.Genomics: 23: 100-113.
N. Spurr,, S. Blanton, R. Bookstein, R. Clarke, R. CottinghamS. Daiger, D. Drayna, P. Faber, S. Horrigan, K. Kas, C kirchgessner, S. Kumar, R. Leach, H-J. LŸdecke, Y. Nakamura, M-J Pebusque, S Ranta, E. Sim, J., L. Sullivan, , L. Tackle, J Vance, M. Wagner, , D. Wells, C. Westbrook. L Yeremko, D. Zaletayev, O Zuffardi and S. Wood. (1995) Report of the Second International Workshop on Human Chromosome 8 Mapping. Cytogenet. Cell Genet. 68: 147-164.
H. Ludecke, M.J. Wagner, J. Nardman, B. LaPillo, P.J. Willems, E.A. Haan, M. Frydman, G.J.H. Hamers D.E. Wells and B. Horstemke. (1995) Molecular dissection of a contiguous gene syndrome: Localization of the genes involved on LGS. Hum. Mol. Genet. 4:31-36.
W.Wuyts, S Ramlakhan, W.V. Hul, J. T. Hecht, A.M.W. van der Ouweland, W.R. Raskin, F.C. Hofstede, E. Reyniers, D.E. Wells, B. deVries, E. U. Conrad, A. Hill, D. Zalatayev, J. Weissenbach, M.J. Wagner, E, Bakker, D.J.J. Halley and P.J. Willems. (1995) Refinement of the multiple exostoses locus (EXT2) to a 3 cM interval on chromosome 11. Am. J. Human Genet. 57: 382-387.
E. Shore, A. Cook, G. Hahn, F. Kaplan, J. Wozney, M.J. Wagner and D.E. Wells. (1995) BMP1 Sublocalizes on human chromosome 8: Molecular anatomy and orthopaedic implications. Clin. Ortho. Rel. Res. 311: 199-209.
J. Hou, J. Parrish, J. Siegel, M. Sapru, Y. Wang, A. Hill, H. Northrup, F.F.B. Elder, E. A. Haan, H. Ludecke, B. Horstemke, M.J. Wagner and D.E. Wells. (1995) A YAC contig spanning the LGS region on human chromosome 8: Sublocalization of EXTI and TRPSI. Genomics 29:87-97.
A. Kurimas, N. Suzuki, S. Kumano, H. Li, D. E. Wells, M. J. Wagner, F. Chen, M. Oshimura. (1995) Construction of 110 cosmid markers and a 4.5 YAC contig on human chromosome 8p12-q11. Genomics 28:147-153.
J. Ahn, H-J. Luedecke, S. Lindlow, W. Horton, B. Lee, M.J. Wagner. B. Horstemke, and D.E. Wells. (1995) Cloning the putative tumour suppressor gene for hereditary multiple exostoses (EXT1). Nature Genetics: 11:137-143.
M. Angrist, D.E. Wells, A. Chakravarti and A. Pandey, (1995) Chromosomal localization of mouse and putative human SRC-like adapter proteins (SLAP) genes. Genomics 30:623-625.
M. Chaffanet, A. Imbert, J. Adelaide, D. LePalslier, M. J. Wagner, D. E. Wells and M-J. Pebusque (1996) A 3.1-Mb YAC contig within the Werner's syndrome region, on the short armof human chromosome 8. Cyto. and Cell Genetics 72:63-68.
J.Z. Gu, M.J. Wagner, E.A. Haan and D.E. Wells. (1996) Detection of a meagbase deletion in a patient with branchio-oto-renal syndrome (BOR) and tricho-rhino-phalangeal syndrome (TRPS); Implications for mapping and cloning the BOR gene. Genomics 31:201-209.
W. Chen, J. Hou, M.J. Wagner, and D.E. Wells. (1996) An integrated physical map covering 25 cM of human chromosome 8. Genomics 32:117-120.
S.H. Blanton, D. Hogue, M. Wagner, D.E. Wells, and J. Hecht. (1996) Hereditary multiple exostoses: Confirmation of linkage to chromosomes 8 and 11. American Journal of Medical Genetics 62:150-159.
J. Z. Gu, X. Lin and D.E. Wells. (1996) B22 subunit of ubiquinone oxidoreductase is a candidate gene for branchio-oto-renal syndrome: Implications for other hearing loss syndromes. Genomics 35: 6-10.
J. Hecht, D. Hogue, Y. Wang, S.H. Blanton, M. Wagner, L. Strong, W. Raskind, M. F. Hansen, and D.E. Wells. (1997) Hereditary multiple exostoses: Mutational studies of familial EXT1 cases and EXT associated malignancies. Am. J. Human Genet. 60: 80-86.
D. E. Wells, A. Hill, X. Lin, J. Ahn, N. Brown, and M. J. Wagner. (1997) Identification of novel mutations in the human EXT1 tumor suppressor gene. Human Genetics 99: 612-615
A. P. Spicer, M. Seldin, A. Olsen, N. Brown, D.E. Wells, N. Doggett, N. Kimata, and J. A. McDonald. (1997) Chromosomal localization of the human and mouse hylauronidase synthetase genes. Genomics 41: 493-497.
X. Lin and D.E. Wells. (1997) Isolation of the mouse cDNA homologous to the human EXT1 gene responsible for Hereditary Multiple Exostosis. DNA Sequence 7:199-202.
A. Taylor, L. Zhang , J. Herrmann, B. Wu, L. Kedes and D. E. Wells. (1997) Cell cycle specific transcription termination within the human H3.3 gene is associated with a specific protein-DNA interaction. Genetical Research 69: 101-110.
H-J. Luedecke, J. Ahn, X. Lin, A. Hill, M.J. Wagner, L. Schomburg, B. Horstemke, and D.E. Wells. (1997) Genomic organization and promoter structure of the Human EXT1 gene. Genomics 40: 351-354.
A. Hill, Y. Harada, E. Takahashi, M. J. Wagner and D. E. Wells. (1997) FRA8E localizes close to the EXT1 gene and to 2 overlapping LGS deletion end points at 8q24.11 Cytogenetics Cell Genetics.78:56-57.
F. Ugolina, M. Chaffanet, R. Houlgatte, D. Patterson, D. E. Wells, C Auffray, D. Birnbaum and M-J. Pebusque. (1997) Regional assignment of 64 human gene transcripts on chromosome 8. Cytogenetics and Cell Genetics 77:197-200.
Xin Lin and Dan Wells. (1997b) Localization of the human H3.3A histone gene, between D1S479 and D1S439 at the distal end of chromosome 1. Genomics 46:526.
X. Shan, A. Bourdeau, A Rhoton, D.E. Wells, E. H. Cohen, B.E. Landgraf and R. Palfree. (1997) Characterization of the human Ly-6 gene 9804 and its mapping to chromosome 8q24.3: Evidence for a Ly-6 multigene family. Journal of Immunology 187-198.
W.R. Raskind, E. U. Conrad, M. Matsushita, E. M. Wijsman, D.E. Wells, L.J. Chapman, M.J. Wagner, J. Houck. (1998) Evaluation of locus heterogeneity and EXT1 mutations in 34 families with hereditary multiple exostoses. Human Mutation I11:231-239 .
X. Lin, L. Gan, W. H. Klein, and D. E. Wells. (1998) Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostosis type 1 gene. Biochemical and Biophysical Research Communications 248: 738-743.
X. Shan, A. Bourdeau, A Rhoton, D.E. Wells, E. H. Cohen, B.E. Landgraf and R. Palfree. (1998) Characterization of the human Ly-6 gene 9804 and its mapping to chromosome 8q24.3: Evidence for a Ly-6 multigene family. Journal of Immunology 1767: 197-208.
X. Lin and D. E. Wells. (1998) Localization of the human H3.3A histone gene, between D1S479 and D1S439 at the distal end of chromosome 1. Genomics 46:526-528.
X. Lin, D.E. Wells and W. Kimberling , S. Kumar (1999) Human NDUFB9 gene: Genomic Organization and exclusion as a candidate gene associated with deafness disorder mapped to chromosome 8. Human Heredity 49:75-80..
X. Lin, Z. Shi, L. Dryer, D. E. Wells* and M. M. Matzuk, (2000) Disruption of Gastrulation and Heparan Sulfate Biosynthesis in EXT1 Deficient Mice. Developmental Biology 224:299-311. (*corresponding author)
M. Hilton, L. GutiŽrrez, L. Zhang, P. Moreno, M. Reddy, N. Brown, Y. Tan, A. Hill, and D.E. Wells, (2001). An Integrated Physical Map of 8q22-24: Use in Positional Cloning and Deletion Analysis of Langer-Giedion Syndrome. Genomics 71:192-199.
D. E. Wells and A. Hill, (2001) Gene Clusters in Encyclopedia of Molecular Medicine, ed. T.Creighton, Wiley.
X. Z Dai and D. E. Wells, (2001) Vg1 Orthology in the Direct Developing Frog, Syrrhophus cystignathoides campi. DNA 11:433-437
A.L. Hill, N. Brown, M.S. Hill, and D.E. Wells (2002) Identification of a Xenopus laevis cDNA for EXT1: A Phylogenic Perspective. DNA 13:85-92..
M. Hilton, J. Sawyer, L. Gutierrez, L. Zhang, T. Kung, and D.E. Wells, (2002) Analysis of novel and recurrent mutations responsible for the Tricho-Rhino-Phalangeal Syndromes. Journal of Human Genetics 47:103-106..
Cermankian, N., Pando, M.P., Tompson, C.L., Pinchak, A.B., Selby, C. Gutierrez, L., Wells, D.E., Cahill, G.M., Sancar, A. and Sassone-Corsi.P., (2002) Cyrptochromes and MAPK dependent induction of vertebrate clocks. Current Biology: 12: 844-848
D. E. Wells and Mathew Hilton, (2003) Chromosome 8 in Encyclopedia of the Human Genome, ed. David N Cooper, McMillian. In press.
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Last updated 6/03.